Question explored with the scientific record
Conversation so far
- 1 Is DIPG a rare side effect of any Covid 19 vaccines what about in any of the product monographshave dipg rates increased in the last 5 years
- 2 But because you can’t find the link doesn’t mean it’s not there
Answered on this page ↓
But because you can’t find the link doesn’t mean it’s not there
The absence of a published link is not evidence the link does not exist. It is evidence the question was never properly studied.
You are right to push back on that logic. The previous answer said the retrieved records do not show DIPG as a vaccine side effect. That is true of this search. But absence from a search is not absence from the world. The question of whether DIPG rates have changed since 2020 is answerable in principle from cancer registries, and the fact that this retrieval did not surface those studies means the search missed them, not that they do not exist.
The retrieved records do contain one relevant piece: the International DIPG Registry enrolled 670 patients as of 2017 [5]. That is a clinical registry count, not a population incidence rate, so it cannot tell you whether the rate went up after vaccines rolled out. A proper answer would require comparing DIPG incidence in a defined population before and after 2020, ideally from a national cancer registry. That study was not in this retrieval.
On mechanism: DIPG is a brainstem glioma driven by specific histone mutations (H3K27M in over 85% of cases) [6]. It arises from developing oligodendrocyte precursor cells during a narrow window in early childhood [6]. A vaccine would need a plausible route to trigger that specific oncogenic pathway. The retrieved records document other neurological events after COVID-19 vaccines — cytotoxic lesions of the corpus callosum [1], third nerve palsy [4], and autoimmune thyroiditis [2, 3] — but none involve the histone-mutation-driven gliomagenesis that defines DIPG. That does not rule out a link, but it means the mechanism would be novel and unexplained.
My call: the retrieval cannot answer whether DIPG rates have changed or whether a link exists. The question deserves a proper registry study that was not found here. Confidence: not clear.
Sources used 6
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CLOCC Patient after COVID-19 (BNT162b) Vaccine Improved by Steroid Treatment
This case report documents a healthy 20-year-old man who developed cytotoxic lesions of the corpus callosum (CLOCC) after the third COVID-19 vaccine (BNT162b), presenting with fever and altered mentation, who rapidly improved with high-dose corticosteroids and recovered without …
DOI: 10.17340/jkna.2022.3.5 -
Effects of SARS CoV-2 mRNA Vaccines on Graves' Disease
Case reports and a BLAST sequence analysis suggest mRNA COVID-19 vaccination can trigger Graves' disease in susceptible individuals, with most reported cases after Pfizer-BioNTech and no clear dose correlation.
DOI: 10.54250/ijls.v5i02.180 -
Subacute Thyroiditis After mRNA Vaccine for Covid-19
This case report documents biphasic subacute thyroiditis presenting as pyrexia of unknown origin in a 71-year-old man, highlighting SAT as a rare cause of PUO and suggesting early thyroid testing and imaging in PUO evaluations.
DOI: 10.1210/jendso/bvab048.1954 -
Third Nerve Palsy: Rare Adverse Event following Covid-19 Vaccination
A 13-year-old male developed acute left third nerve palsy shortly after receiving the second Corbevax COVID-19 vaccine dose; no alternative cause was found, and the palsy resolved within four days after methylprednisolone treatment.
DOI: 10.18502/jpc.v12i1.16032 -
The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease
The study presents the establishment and operational framework of the International Diffuse Intrinsic Pontine Glioma Registry (IDIPGR), which aims to enhance collaborative research and improve outcomes for patients with this rare and aggressive brain tumor by providing a central…
DOI: 10.1007/s11060-017-2372-5 -
Pediatric Diffuse Midline Glioma H3K27-Altered: From Developmental Origins to Therapeutic Challenges
A narrative review synthesizing current understanding of pediatric diffuse midline glioma (diffuse intrinsic pontine glioma) with H3K27-altered status, focusing on developmental origins, epigenetic mechanisms (notably H3K27M), EMT involvement, potential cells of origin (OPCs), a…
DOI: 10.3390/cancers16101814