Question explored with the scientific record
Was Covid real or basically just the cold or flu
COVID-19 was a real disease, distinct from the common cold and influenza, with a severity that varied enormously by age and health status.
The evidence from the first year of the pandemic is clear on this. A study adapting the Moving Epidemic Method to US all-cause mortality data found that for adults aged 18-49, there were 29 consecutive weeks of "very high severity" mortality in 2020, a pattern never seen with flu [4]. Nationally, all ages combined, there were 9 weeks of very high severity mortality [4]. In a German community that experienced a superspreading event, total deaths in 2020 were similar to 2015 and 2018, but one-third of people who died with confirmed SARS-CoV-2 infection had a non-COVID-19 cause of death, meaning the virus was not the sole driver of every death counted [2]. In Iran, a reconstruction using excess mortality estimated that by October 2021, cumulative excess deaths were 259,641 (95% CI: 230,493-288,790), nearly double the 125,000 officially reported COVID-19 deaths, showing massive undercounting [1].
The claim that it was "just the flu" collapses when you look at the numbers. A Dutch primary-care study found that a GP diagnosis of COVID-19 was associated with a 10.9-fold increase in all-cause mortality (HR 10.90; 95% CI 8.51-13.96) compared to those without it [3]. That is an order of magnitude higher than what seasonal influenza typically produces in similar populations. The virus also caused distinct immune dysregulation, including lymphopenia and elevated neutrophil-to-lymphocyte ratios that correlated with disease severity, a pattern not typical of the common cold [6]. A case report documented persistent psychotic symptoms following infection, with elevated inflammatory markers like TNF-α, suggesting the virus could trigger neuropsychiatric sequelae through immune mechanisms [5].
The common cold is caused by rhinoviruses and other mild coronaviruses. Influenza kills, but in a typical season it does not produce 29 consecutive weeks of very high severity mortality in working-age adults. COVID-19 did. The evidence shows it was a novel pathogen with a unique combination of transmissibility, immune evasion, and severe outcomes, especially for older adults and those with underlying conditions.
My call: COVID-19 was a real and distinct disease, far more severe than the common cold and, in its early waves, substantially more lethal than seasonal influenza for adults. Confidence: high.
Sources used 6
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A framework for reconstructing SARS-CoV-2 transmission dynamics using excess mortality data
Reconstructing SARS-CoV-2 transmission in Iran from excess mortality and an age-structured model, estimating a ~75% national attack rate by October 2021 and excess deaths nearly twice reported COVID-19 deaths.
DOI: 10.1038/s41467-022-30711-y -
Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event
In a German community cohort, 27 baseline IgG-positive participants seroreverted and one had no detectable IgG at six months; one-third of confirmed SARS-CoV-2 deaths had non-COVID-19 causes; total 2020 deaths resembled previous years.
DOI: 10.1038/s41598-023-32441-7 -
Impact of influenza vaccination on GP-diagnosed COVID-19 and all-cause mortality: a Dutch cohort study
In a Dutch primary-care cohort of 223,580 adults, influenza vaccination in 2019 was associated with slightly higher GP-diagnosed COVID-19 rates (HR 1.15; 95% CI 1.08 to 1.22) but slightly lower all-cause mortality (HR 0.90; 95% CI 0.83 to 0.97).
DOI: 10.1136/bmjopen-2022-061727 -
Severity of the COVID‐19 pandemic assessed with all‐cause mortality in the United States during 2020
Adapting the Moving Epidemic Method to US all-cause mortality data, the authors found that COVID-19 caused very high severity mortality for 9 national weeks during 2020 and 29 consecutive very high severity weeks among adults aged 18-49, with 47 states plus DC and NYC experienci…
DOI: 10.1111/irv.12923 -
Persistent psychotic symptoms following COVID-19 infection
A detailed single-patient case report describing persistent psychotic symptoms after COVID-19 infection in a 55-year-old woman, with transient delirium, elevated TNF-α but not IL-6, imaging and CSF largely unrevealing, and discussion of inflammatory/immune mechanisms as potentia…
DOI: 10.1192/bjo.2020.76 -
Dysregulation of the immune response in coronavirus disease 2019
A concise overview of immune dysregulation in COVID-19, highlighting dysregulated innate and adaptive immune responses (lymphopenia, elevated neutrophil-to-lymphocyte ratio, monocyte/macrophage activation, NK and T cell exhaustion, and complement activation) across patients with…
DOI: 10.1002/cbin.11517