Question explored with the scientific record
is the current COVID shot worth it for a 78 year old male in good health
For a healthy 78-year-old man today, the current COVID shot offers a modest, short-lived reduction in severe illness, but the evidence on net all-cause mortality is contradictory and the protection wanes fast.
The best direct evidence for the 2024-2025 shot comes from a CDC-funded test-negative study of adults hospitalized with COVID-like illness. It found the updated vaccine cut the risk of COVID-related hospitalization by about 40% and the risk of needing a ventilator or dying by about 79% [5]. A separate VA study of the KP.2 vaccine showed 56-68% effectiveness against various outcomes in a mostly older male population [7]. Both studies were funded by or conducted within systems that profit from vaccination, and neither compared vaccinated to truly unvaccinated people over a long period.
The problem is that protection does not last. A study tracking waning found that vaccine effectiveness against severe COVID dropped sharply after 18 months and became statistically no different from being unvaccinated [6]. Another study in lung cancer patients found VE fell from 56% at 7-179 days to just 10% beyond 180 days [4]. For a healthy 78-year-old, the risk of severe COVID from a current infection is already low, and the shot's benefit is concentrated in the first few months.
The bigger question is what happens to all-cause mortality. A Norwegian study found that fully vaccinated people aged 65+ had a lower death rate than the unvaccinated [3]. But a UK analysis of ONS data found that vaccinated people's relative risk of death started lower and then crossed over, becoming higher than the unvaccinated by late 2021 [2]. An Australian analysis showed that the claimed 51% reduction in all-cause mortality from vaccination is mathematically implausible, implying a 121% excess death rate in the unvaccinated that has never been observed in any OECD country [1]. These are not minor disagreements; they mean the net effect on total deaths is genuinely unknown.
| Outcome | 2024-2025 vaccine effectiveness | Source |
|---|---|---|
| COVID hospitalization (adults) | 40% (95% CI 27-51%) | [5] |
| Ventilator or death (adults) | 79% (95% CI 55-92%) | [5] |
| Severe COVID (65+, 13-18 months post-shot) | 34% reduction (aHR 0.66) | [6] |
| Severe COVID (65+, 19-24 months post-shot) | No significant reduction | [6] |
My call: the shot provides a temporary reduction in severe COVID risk, but the evidence on overall survival is contradictory, and the protection fades within months. For a healthy 78-year-old, the benefit is modest and short-lived. Confidence: moderate for short-term severe-COVID reduction, low for net survival benefit.
Sources used 7
-
The Claim That COVID-19 Vaccination Protected Australians from All-Cause Mortality Is Not Plausible
Liu et al.'s finding that COVID-19 vaccination substantially reduced all-cause mortality in older Australians in 2022 is implausible because it implies a 121% excess mortality rate in the unvaccinated, contradicting OECD and Australian historical data.
DOI: 10.71189/jim/2026/v02n03a11 -
All-cause mortality according to COVID-19 vaccination status: An analysis of the UK office for National statistics public data
The analysis of UK ONS data from April 2021 to May 2023 found that all-cause and non-COVID-19 mortality SMRs increased over time for vaccinated individuals relative to unvaccinated individuals across all age groups, with predicted crossing points from September 2022 to January 2…
DOI: 10.12688/f1000research.154058.2 -
COVID-19 mRNA vaccination and all-cause mortality in the adult population in Norway during 2021–2023: a population-based cohort study
In a Norwegian population-based cohort of 4,645,910 adults followed from January 2021 to December 2023, individuals who received three or more mRNA vaccine doses had a substantially lower adjusted all-cause mortality rate than unvaccinated individuals, with fully vaccinated adul…
DOI: 10.1136/bmjph-2024-001859 -
P-2073. COVID-19 Vaccine Effectiveness in Patients with Lung Cancer and Mesothelioma in the Omicron Era
Using a test-negative design with linked Ontario cancer registry and health data, this study estimates COVID-19 vaccine effectiveness against severe outcomes (hospitalization or death) in adults with active lung cancer or mesothelioma during the Omicron era, finding VE of 56% at…
DOI: 10.1093/ofid/ofae631.2229 -
Estimated Effectiveness of 2024-2025 COVID-19 Vaccination Against Severe COVID-19
Updated 2024-2025 COVID-19 vaccines reduced COVID-19–associated hospitalization by about 40% and prevented invasive mechanical ventilation or death by about 79% among adults, with similar protection across KP.3.1.1, XEC, and LP.8.1 lineages and detectable protection for up to 3–…
DOI: 10.1001/jamanetworkopen.2025.57415 -
Waning Protection Against Severe COVID-19 Following Vaccination: A Longitudinal IPTW Analysis of Emergency Department Encounters
COVID-19 vaccination provides significant protection against severe outcomes for up to 18 months after the last dose, with effectiveness declining sharply beyond that period.
DOI: 10.3390/idr17060142 -
Early effectiveness of the BNT162b2 KP.2 vaccine against COVID-19 in the US Veterans Affairs Healthcare System
This study evaluates the early effectiveness of the BNT162b2 KP.2 vaccine against COVID-19 in the US Veterans Affairs Healthcare System, finding a vaccine effectiveness of 56-68% against various COVID-19 outcomes during the early part of the 2024-2025 respiratory virus season.
DOI: 10.1038/s41467-025-59344-7