Given the above circumstances, what can I do to reduce inflamation?

The short version: what you describe — improved diet but stuck weight despite a history of shame and binge eating — fits the known biology, but the evidence retrieved here does not test it directly.

The studies in this batch are mostly about knee osteoarthritis and weight stigma in young women, not about metabolic resistance in a person with decades of weight-related shaming. A 2011 study found that perceived weight discrimination predicted worsening health and disability over a 10-year span in US adults [3]. That matches your pattern. A 2018 study found that women who felt “overweight” (through wearing an obese suit) ate more snack food afterward, while men did not [1]. A 2016 Iranian study found that lower self-stigma was linked to better quality of life and less distress in overweight women [2]. These show that stigma changes behavior and health. They do not measure inflammation directly.

The missing piece is the one you reported: a binge eating diagnosis. A 2014 daily diary study of 50 overweight women found that each woman experienced on average 3 weight-stigma events per day, and that more stigma was linked to worse diet quality but not to exercise [4]. Stigma drives disordered eating. Disordered eating, especially bingeing, keeps the stress-inflammation loop active. The animal and cellular studies in the previous answer showed that this inflammation makes fat tissue hold onto fat. The human studies here show that the stigmatizing events happen every day, not once in a while.

My call: the evidence for a stigma-inflammation-stuck-weight loop in someone like you is indirect but coherent across the studies. The direct trial — follow people with childhood weight stigma into adulthood and measure metabolic resistance — has not been done. The evidence supports that what you describe is a biological pattern, not a personal failure. Confidence: moderate.