Question explored with the scientific record
Conversation so far
- 1 Does magnesium status affect glutathione synthesis or levels in the body?
- 2 Have any human studies measured glutathione after magnesium supplements?
Answered on this page ↓
Have any human studies measured glutathione after magnesium supplements?
No. This search surfaced no human study that measured glutathione before and after magnesium supplements.
The 35 records here are almost all about magnesium's effect on other things: blood pressure, insulin, inflammation, bone, COVID outcomes. None of them measured glutathione as an outcome. The closest is a rat study where magnesium supplementation reduced oxidative stress markers in cadmium-exposed animals, but it measured lipid peroxidation, not glutathione [2]. A plant study tracked glutathione in algae under cadmium stress, which tells you nothing about humans [1].
So the honest answer to your exact question is that this search found no human trial or cohort that dosed magnesium and read glutathione. That is a fact about this search, not proof the study doesn't exist. Human trials measuring glutathione after magnesium would be the study that settles it, and this retrieval did not surface one.
My call: no human study in this evidence measured glutathione after magnesium supplementation, and I cannot tell you whether such a study exists outside this search. Confidence: moderate that the gap is real in this retrieval, low about the wider literature.
Sources used 2
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Characterization of Cadmium Binding Protein from Scenedesmus quadricauda and Cd Toxicity Reversal by Phytochelatin Constituting Amino Acids and Citrate
This study characterizes a cadmium-binding protein from the freshwater alga Scenedesmus quadricauda, shows it is phytochelatin-like with cysteine and sulfide features, and demonstrates that phytochelatin-constituting amino acids and citrate can reverse Cd toxicity, with glutathi…
DOI: 10.1016/S0176-1617(11)80927-2 -
Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation
This study investigates the protective effects of magnesium supplementation against cadmium-induced oxidative stress in the liver, kidneys, and testes of adult male rats, revealing that magnesium can reduce cadmium accumulation and lipid peroxidation in these organs.
DOI: 10.1016/j.etp.2006.02.012