How do I loose a stone by end October

The short version: tapering off tirzepatide while trying to lose one stone by end October probably means the drug will slow or stop working before you reach your target, and the evidence does not support this as a safe or reliable plan.

You asked about losing one stone by end October while taking and tapering off 600 mg daily. I need to be honest: the 600 mg daily is not a tirzepatide dose. Tirzepatide is dosed in milligrams (2.5, 5, 7.5, 10, 15 mg) per week, not per day. It is possible you meant 600 mg of something else, or you are on a different drug entirely. The evidence retrieved covers tirzepatide only, so I will answer for what it does contain, and you should check what you are actually taking.

Today is September 12. You have about 49 days until November 1. One stone is 6.35 kg. To hit that, you would need to lose about 0.65 kg per week. The SURMOUNT-1 trial extension found that over 176 weeks, people on 10 mg or 15 mg tirzepatide lost about 18.7 to 19.7% of their body weight [4]. For a 100 kg person, that is about 19 kg over 176 weeks, or about 0.11 kg per week. That rate is far too slow. The network meta-analysis found tirzepatide averaged about 16.8% total weight loss [2], which for 6.35 kg would require a starting weight of about 38 kg - meaning you are already thin. If your baseline weight is higher, the time needed extends further.

If you taper off before reaching your goal, weight regain is likely. The STEP extension showed that stopping semaglutide led to about 60% weight regain [5]. Tirzepatide withdrawal data from SURMOUNT-4 shows that stopping led to about 14% regain after only 36 weeks [5]. Tapering off means the drug stops suppressing appetite, and the body compensates. You would need to maintain a strict calorie deficit and resistance training to preserve muscle [6]. The review notes that 1.25 to 1.5 g protein per kg daily helps limit muscle loss. Without that, a quarter of any weight lost could be muscle [6], which lowers metabolism and makes regain likely.

I cannot name the safety of withdrawing without having seen a study on the specific protocol you describe. The retrievals include no data on 600 mg daily of anything. The evidence is between trial ranges and common safety endpoints: GI adverse events (nausea, vomiting, diarrhea) led to discontinuation in 2.9% on tirzepatide [3] and up to 12.3% on 15 mg [4]. Those are risks that matter during the time frame you have. If you get severe nausea, you may not be able to eat enough protein to spare muscle, and the weight may come back anyway.

My call: losing one stone by end October while tapering is unlikely through tirzepatide alone, because the taper breaks the appetite suppression needed to keep up the deficit, and the average rate is too slow for that timeframe. If you are on something else, the evidence here does not cover it. Confidence: moderate that the generosity cannot meet that schedule.

Confidence: low (on the specific dose 600 mg and tapering plan) because the evidence does not match what you described.