I’m not well with some kind of Covid or flu. Should I pause my Mounjaro injection ?

The short version: the retrieved evidence does not directly study whether to pause Mounjaro during an acute respiratory illness, so the answer rests on general clinical reasoning about how the drug works and what the acute illness does to the body.

Mounjaro (tirzepatide) slows gastric emptying and can cause nausea, vomiting, and diarrhea, especially in the first weeks [3]. An acute viral illness like COVID-19 or influenza often brings its own gastrointestinal symptoms, fever, and dehydration. Combining the two could make it harder to keep food and fluids down, raising the risk of dehydration or electrolyte imbalance. The evidence does not contain a single study that tested whether continuing or pausing the drug changes recovery time, complication rates, or symptom severity during an acute respiratory infection.

The drug also has well-documented cardiovascular and metabolic effects that may be relevant during illness. Tirzepatide reduces blood pressure and heart rate in some patients [2], and acute infections already stress the cardiovascular system. A 2026 JAMA study found tirzepatide lowered all-cause mortality and myocardial infarction risk over four years in high-risk patients [1], but that is a long-term effect, not guidance for a week of acute illness.

My call: there is no evidence in these records that pausing a single dose of Mounjaro during a short illness is harmful, and there is plausible reason to skip it if you are vomiting, dehydrated, or cannot keep food down. The safest course is to ask your prescribing doctor, but if you cannot reach them, skipping one dose is unlikely to undo months of metabolic benefit. Confidence: moderate - the evidence is thin on this exact question, but the reasoning from known pharmacology is straightforward.