Question explored with the scientific record
what is ip36 deletion and why is it listed on pfizer effects paper
The short version: the evidence you retrieved does not contain a Pfizer effects paper, so the question cannot be answered from what was provided.
The evidence you supplied includes a 2023 narrative review comparing Moderna and Pfizer COVID-19 vaccines [32], but it does not mention "IP36 deletion" anywhere. The other 31 records cover genomic deletions in contexts ranging from cognitive ability [1] to African swine fever virus [4] to Alzheimer's disease [22] to yeast [30]. None of them are a Pfizer safety or effects paper, and none list IP36 deletion.
IP36 deletion is a standard cytogenetic notation: a deletion on the short arm of chromosome 1 at band 36. It is a known genomic variant, sometimes pathogenic and sometimes benign depending on the exact breakpoints and genes involved. But why it would appear on a Pfizer document is impossible to say from this retrieval. It could be a pharmacogenomic marker, a incidental finding from a participant's sequencing, or a label from a gene-expression assay used in the study. Without the actual Pfizer paper in the evidence, any guess is speculation.
My call: the evidence does not answer this question. Confidence: not clear.
Sources examined 32
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Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex
This study investigates the impact of genomic deletions and duplications on cognitive ability across the human cerebral cortex, revealing a mirror effect where deletions and duplications have opposing influences on cognitive performance in different cortical regions.
DOI: 10.1101/2025.01.06.631492 -
High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome
This study investigates the frequency of large genomic deletions in the SMAD4 and BMPR1A genes among 80 unrelated families with juvenile polyposis syndrome (JPS), revealing a significant genotype-phenotype correlation and implications for clinical management.
DOI: 10.1136/jmg.2007.052506 -
A Clinical and Molecular Genetic Study in 11 Chinese Children With Peutz‐Jeghers Syndrome
This study investigates the spectrum of STK11 gene mutations in 11 Chinese children with Peutz-Jeghers syndrome using multiplex ligation-dependent probe amplification (MLPA) and direct sequencing, revealing both large genomic deletions and novel point mutations.
DOI: 10.1097/mpg.0000000000001316 -
Deletion at the 5’-end of Estonian ASFV strains associated with an attenuated phenotype
This study characterizes an African swine fever virus (ASFV) strain from Estonia that exhibits reduced virulence, as evidenced by the survival of a significant proportion of infected pigs and the identification of a specific genomic deletion.
DOI: 10.1038/s41598-018-24740-1 -
Large genomic rearrangements in MECP2
This study utilized the Multiplex Ligation-dependent Probe Amplification (MLPA) technique to identify large genomic deletions in the MECP2 gene among 45 Rett syndrome patients previously tested negative for mutations, revealing that such deletions are a significant cause of clas…
DOI: 10.1002/humu.9320 -
Multiplex Ligation-Dependent Probe Amplification Using a Completely Synthetic Probe Set
This study presents a novel approach to multiplex ligation-dependent probe amplification (MLPA) using synthetic probes to efficiently screen for genomic deletions across multiple loci, demonstrating its reliability and potential for diagnostic applications.
DOI: 10.2144/04373st04 -
Transcriptional explorations of CAPN3 identify novel splicing mutations, a large‐sized genomic deletion and evidence for messenger RNA decay
This study identifies novel splicing mutations and a large genomic deletion in the CAPN3 gene, which are implicated in limb-girdle muscular dystrophy type 2A (LGMD2A), and provides evidence for messenger RNA decay as a mechanism for under-expression of CAPN3.
DOI: 10.1111/j.1399-0004.2007.00906.x -
Highly efficient genome editing in Bacillus subtilis via miniature DNA nucleases IscB
This study successfully establishes a highly efficient genome editing system in Bacillus subtilis using the miniature DNA nuclease IscB, enabling precise deletions and integrations of large genomic fragments.
DOI: 10.1101/2025.02.11.637773 -
Pathogenic and nonpathogenic deletions in two families with Duchenne muscular dystrophy
This study identifies two independent, nonpathogenic deletions in the Duchenne/Becker muscular dystrophy gene in normal males from two families, emphasizing the need for caution in using genomic deletions for clinical predictions of Duchenne muscular dystrophy.
DOI: 10.1002/ajmg.1320330123 -
Maize BMS cultured cell lines survive with massive plastid gene loss
Three independently maintained maize Black Mexican Sweet (BMS) cultured cell lines (BMS-C, BMS-G, BMS-D) were characterized to reveal massive plastid genome deletions in two lines and a largely intact plastid genome in the third, with limited plastid transcription yet preserved …
DOI: 10.1007/s00294-003-0408-1 -
Sequencing and analysis of the whole genome of Indian Gujarati male
This study presents the whole genome sequencing and analysis of a Gujarati Indian male, revealing over 3.9 million single nucleotide variants and 393,000 small insertions and deletions, including novel variants that contribute to the understanding of health, disease relevance, a…
DOI: 10.1016/j.ygeno.2018.02.003 -
Identification of a de novo FOXP1 mutation and incidental discovery of inherited genetic variants contributing to a case of autism spectrum disorder and epilepsy
FOXP1 3' UTR de novo variant in Patient 1 is associated with altered FOXP1 regulation and reduced FOXP1 protein expression, supporting FOXP1 haploinsufficiency as a contributor to ASD/epilepsy in this case, with inherited pharmacogenomic variants and polygenic factors potentiall…
DOI: 10.1002/mgg3.751 -
deCYPher: Star Allele-Resolution Computational Framework of Pharmacogenes for Haplotype-Resolved Long-Read Assemblies
deCYPher is a haplotype-resolved, long-read–assembly–based framework that accurately resolves PharmVar/CPIC pharmacogene star alleles across nine clinically important genes, detects structural variants and CNVs, and outperforms existing tools in diplotype calls.
DOI: 10.1101/2025.10.13.681303 -
Thailand mutation and variation database (ThaiMUT)
ThaiMUT is a web-based national/ethnic mutation and variation database for the Thai population, cataloging mutations from PubMed and local publications and integrating SNP data to support mutation screening, pharmacogenomics, and comparative population genetics.
DOI: 10.1002/humu.20787 -
The genetic landscape of the human solute carrier (SLC) transporter superfamily
Comprehensive mapping of the human SLC transporter gene variability across 141,456 individuals reveals extensive rare variation, strong ethnogeographic structuring, and a substantial contribution of rare variants to transporter function and Mendelian disease risk.
DOI: 10.1007/s00439-019-02081-x -
The potential of whole genome sequencing in pharmacogenetics: a retrospective health record study in rare disease patients
Whole-genome sequencing of 1,000 individuals from 389 families (with a 359-person drug-prescription subcohort) reveals a high prevalence of actionable pharmacogenetic variants (97% overall; 98.7% in unrelated index cases) and shows that CNVs and rare variants can modify therapy …
DOI: 10.1038/s41431-026-02025-w -
Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon
In Cameroon, a prospective clinical-genetic study of 436 HbSS sickle cell patients identifies clinical and multiple genetic predictors of vaso-occlusive pain episodes and health-care utilization, highlighting associations with 3 pain-related SNPs (CACNA2D3 rs6777055, DRD2 rs4274…
DOI: 10.1111/bjh.15011 -
Novel CYP2A7/CYP2A6 germline hybrids associated with mutation burden in lung cancer revealed by whole-genome long-read sequencing
The study uses combined long-read and short-read whole-genome sequencing to identify three novel CYP2A7/CYP2A6 germline hybrids and related CYP2A6 deletions in 20 Japanese cancer patients, finding that deletion-type germline CYP2A6 status associates with lower tumor mutation bur…
DOI: 10.1038/s41598-025-29542-w -
Regulation associated modules reflect 3D genome modularity associated with chromatin activity
Active histone marks reveal regulation-associated modules (RAMs) that map to functional 3D genome modularity, coordinating promoter–enhancer interactions and ecDNA localization, distinct from TADs/LADs/compartments, and enriched for cancer mutations with boundary deletions predi…
DOI: 10.1038/s41467-022-32911-y -
Pathogenic Germline Variants in 10,389 Adult Cancers
A comprehensive pan-cancer analysis of pathogenic germline variants in 10,389 adult cancers across 33 TCGA cancer types, identifying 853 pathogenic/likely pathogenic germline variants (in 8% of cases), uncovering patterns of activating oncogene variants, tumor suppressor LOH, co…
DOI: 10.1016/J.CELL.2018.03.039 -
Careful with That Axe, Gene, Genome Perturbation after a PEG-Mediated Protoplast Transformation in Fusarium verticillioides
This study investigates the genomic perturbations in Fusarium verticillioides following PEG-mediated protoplast transformation and the implications of these changes on phenotypic variability and gene expression.
DOI: 10.3390/toxins9060183 -
Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s Disease
A large-scale, region- and cell-type-resolved single-cell multi-omic atlas of Alzheimer's disease (AD) in human brain that jointly profiles DNA methylation and 3D genome architecture across three vulnerable regions, revealing region-specific epigenomic reorganization, novel AD-a…
DOI: 10.1101/2025.09.29.678849 -
Predicting gene expression changes from chromatin structure modification
This study presents a computational framework that links chromatin structure modifications to gene expression changes, demonstrating how TAD boundary deletions can affect enhancer-promoter interactions and gene transcription levels.
DOI: 10.1038/s41540-025-00510-4 -
Polymorphisms in a pseudogene highly homologous to PMS2
This study identifies polymorphisms in a non-expressed pseudogene highly homologous to the PMS2 gene, which could be misinterpreted as mutations in PMS2, potentially leading to erroneous conclusions regarding hereditary nonpolyposis colorectal cancer (HNPCC) and Turcot's syndrom…
DOI: 10.1002/1098-1004(200012)16:6<530::AID-HUMU15>3.0.CO;2-6 -
A cytogenetic footprint for mammary carcinomas induced by PhIP in rats
This study uses comparative genomic hybridization to characterize chromosomal losses in PhIP-induced rat mammary carcinomas, distinguishes them from DMBA-induced tumors, and develops gene-recovery microdissection (GRM) and rolling circle amplification (RCA) methods to map expres…
DOI: 10.1016/s0300-483x(02)00261-5 -
SMCHD1 is a novel target for gene-activation therapy to treat Prader-Willi Syndrome
Deleting SMCHD1 in human neural cells activates maternal PWS genes and improves disease-relevant phenotypes in a Magel2-null mouse model, supporting SMCHD1 as a potential gene-activation therapy target for Prader-Willi Syndrome.
DOI: 10.64898/2026.05.13.725051 -
Genome-wide analysis of DNA copy-number changes using cDNA microarrays
The study introduces a cDNA microarray-based comparative genomic hybridization (aCGH) method to map genome-wide DNA copy-number variations in breast cancer cell lines and tumors, achieving high-resolution detection of amplifications and deletions and enabling parallel analysis o…
DOI: 10.1038/12640 -
Multi-Omics Characterization of a KIF1C Structural Variant in a Patient with a Complex Movement Disorder Partially Responsive to Deep Brain Stimulation
A biallelic KIF1C exon 17-18 deletion detected by Optical Genome Mapping in a patient with infantile-onset movement disorder is linked to reduced KIF1C expression and abnormal splicing, with GPi deep brain stimulation providing partial dystonia relief, illustrating CNVs as under…
DOI: 10.1007/s12311-026-01963-x -
The aging transcriptome: a condition-dependent response to a deteriorating soma
By experimentally reducing organismal condition in young female Drosophila melanogaster and comparing the resulting transcriptional changes to natural aging, the study reveals substantial overlap between age-related and condition-induced gene expression changes, supporting a pla…
DOI: 10.64898/2025.12.22.696078 -
Global changes in gene expression associated with phenotypic switching of wild yeast
Three isogenic Saccharomyces cerevisiae strains representing wild, domesticated and feral phenotypes reveal that environmental stress induces reversible switching to structured biofilm colonies, linked to transcriptome reprogramming, cell-wall remodeling (including FLO11), ECM p…
DOI: 10.1186/1471-2164-15-136 -
Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation
This study uses epithelial SCAP/INSIG/SREBP signaling manipulation in mouse perinatal lungs to map dynamic genomic and lipid regulatory programs, revealing stage-specific effects on lipogenesis, surfactant-associated genes, and cross-talk with Wnt and glucocorticoid signaling du…
DOI: 10.1371/journal.pone.0091376 -
The Systematic Research of The Comparison of Moderna Covid-19 Vaccine and Pfizer Covid-19 Vaccine
A narrative review comparing Moderna and Pfizer/BioNTech COVID-19 vaccines, outlining their mechanisms, clinical efficacy including against the Delta variant, safety profiles, storage considerations, and future directions.
DOI: 10.54097/hset.v45i.7384