Question explored with the scientific record
Is Paget’s disease a known vaccine side effect
Paget’s disease is not a known or recognized vaccine side effect in the published literature, and the evidence retrieved here contains zero reports linking any vaccine to Paget’s disease.
The records you see are a sample of one search, not the full literature. They cover VAERS-based safety studies for several vaccines [1, 2, 4, 5, 6, 7], a few modeling papers [3], and one 2026 study on the genetic basis of Paget’s disease itself [8]. None of them mention Paget’s disease as an adverse event. That silence is not proof of safety—it is a fact about what this search found.
Paget’s disease is a chronic bone disorder driven by overactive osteoclasts (bone-resorbing cells). The 2026 study shows that a mutation in the ZNF687 gene can expand osteoclast precursors and cause severe Paget’s [8]. That is a genetic mechanism, not an immune or inflammatory trigger from a vaccine. No study in this retrieval tested whether vaccination could influence that pathway, and no study reported a case.
The question is whether Paget’s disease is a known side effect. The answer is no. The evidence does not show it, and the mechanism does not suggest it. If you are asking because you or someone you know developed Paget’s after a vaccine, that is a temporal association, not a proven link. The burden of proof would be on anyone claiming causation, and that evidence does not exist here.
My call: Paget’s disease is not a recognized vaccine adverse event. Confidence: high, based on the absence of any signal in the retrieved literature and the genetic rather than immune-driven nature of the disease.
Sources used 8
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The Ontology of Vaccine Adverse Events (OVAE) and its usage in representing and analyzing adverse events associated with US-licensed human vaccines
The study presents the Ontology of Vaccine Adverse Events (OVAE), a framework developed to systematically represent and analyze adverse events associated with US-licensed human vaccines, facilitating better understanding and classification of vaccine-specific adverse events (VAE…
DOI: 10.1186/2041-1480-4-40 -
Preparation for global introduction of inactivated poliovirus vaccine: safety evidence from the US Vaccine Adverse Event Reporting System, 2000–12
This study analyzes adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) following the administration of the inactivated poliovirus vaccine (IPV) from 2000 to 2012, finding a low incidence of serious adverse events and no new safety concerns associate…
DOI: 10.1016/s1473-3099(15)00059-6 -
The impact of rare but severe vaccine adverse events on behaviour-disease dynamics: a network model
A network-based computational model coupling infection spread, vaccination decisions, and diffusion of information about adverse events to show that rare but severe vaccine adverse events can dramatically lengthen outbreaks, with global information dissemination generally boosti…
DOI: 10.1038/s41598-019-43596-7 -
Safety review of the purified chick embryo cell rabies vaccine: Data from the Vaccine Adverse Event Reporting System (VAERS), 1997–2005
This study reviews adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) following the administration of the Purified Chick Embryo Cell (PCEC) rabies vaccine in the U.S. from 1997 to 2005, finding that most reported adverse events were non-serious and con…
DOI: 10.1016/j.vaccine.2007.02.075 -
Post-licensure surveillance of quadrivalent live attenuated influenza vaccine United States, Vaccine Adverse Event Reporting System (VAERS), July 2013–June 2014
This study analyzes reports from the Vaccine Adverse Event Reporting System (VAERS) regarding the safety of the quadrivalent live attenuated influenza vaccine (LAIV4) during its first season of use, finding no concerning patterns and highlighting the need for education on proper…
DOI: 10.1016/j.vaccine.2015.01.080 -
Post-licensure safety monitoring of quadrivalent human papillomavirus vaccine in the Vaccine Adverse Event Reporting System (VAERS), 2009–2015
This study analyzes the safety of the quadrivalent human papillomavirus vaccine (4vHPV) using data from the Vaccine Adverse Event Reporting System (VAERS) from 2009 to 2015, finding no new or unexpected safety concerns.
DOI: 10.1016/j.vaccine.2018.02.034 -
Adverse events after Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccine administered to adults 65 years of age and older reported to the Vaccine Adverse Event Reporting System (VAERS), 2005–2010
This study reviews adverse event reports following the off-label administration of the Tdap vaccine to adults aged 65 years and older, utilizing data from the Vaccine Adverse Event Reporting System (VAERS) from 2005 to 2010, and finds no significant safety concerns warranting fu…
DOI: 10.1016/j.vaccine.2011.05.100 -
ZNF687 couples bone marrow myeloid progenitor dynamics to osteoclastogenesis in severe Paget’s disease of bone
ZNF687/Zfp687 controls bone marrow myeloid progenitor output and osteoclastogenesis: loss reduces osteoclast progenitors, GMPs, and bone resorption, while the P937R mutation expands progenitors and enhances human iPSC clonogenic output.
DOI: 10.64898/2026.08.11.744220