Question explored with the scientific record
Conversation so far
- 1 Did research in to treatment of Down syndrome decrease after prenatal screening and selective abortion in public health became routine?
- 2 Did research funding in to Down syndrome decrease after prenatal screening and selective abortion in public health became routine?
Answered on this page ↓
Did research funding in to Down syndrome decrease after prenatal screening and selective abortion in public health became routine?
The short version: nothing in front of me tracks Down syndrome research funding before and after routine prenatal screening, so the funding question stays open.
The closest thing in this retrieval is a bibliometric study of Angelman syndrome, a different genetic condition [9]. It maps publication trends, funding sources, and the shift toward therapeutic trials over about 50 years [9]. That is the method your question needs, but it was applied to Angelman, not Down syndrome, so it cannot answer whether Down syndrome funding fell.
The Down syndrome record here is a 1989 autopsy comparison showing Down syndrome patients had much milder atherosclerosis than other groups [18]. That is a disease finding, not a funding trend. The rest of the block is off-topic strays: Gitelman syndrome [1], hypoglossia [2], SIDS positioning [3], hepatorenal syndrome [4], fatty pancreas [5], Pfeiffer syndrome [6], burning mouth [7], Marfan [8], myeloma [10], fathers of disabled children [11], a text-corpus paper [12], leukorrhea [13], metabolic syndrome genetics [14], a dog case [15], metabolic definitions [16], aging glycans [17], fitness [19], and Alzheimer's neuropsychiatry [20].
| What the question needs | What this retrieval has |
|---|---|
| Grant and publication counts over time | Angelman bibliometrics only [9] |
| Down syndrome treatment trial trends | None |
| Screening-era funding comparison | None |
Outside these records, the logic is simple: fewer affected births means a smaller market, and market size shapes industry investment. That is a mechanism, not a measured decline. Settling it needs PubMed and grant-database counts for Down syndrome treatment research across the screening era.
My call: the funding question is unanswered here, and the Angelman paper shows the right method exists without being run on Down syndrome in this evidence. Confidence: not clear.
Sources used 20
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Clinical and genetic analyses of Chinese patients with Gitelman syndrome
This study evaluates the genotype-phenotype relationship of Gitelman syndrome in Chinese patients, identifying specific mutations in the SLC12A3 gene and their clinical implications.
DOI: 10.4238/gmr.15027859 -
Treatment of Hypoglossia-Hypodactyly Syndrome without Extremity Anomalies
This study reports three cases of hypoglossia-hypodactyly syndrome without limb deformities, detailing the surgical interventions and their positive outcomes on speech, swallowing, and mastication.
DOI: 10.1097/00006534-200008000-00004 -
The Importance of the Position of Infants on the Sudden Infant Death Syndrome
This study proposes that oropharyngeal airway obstruction due to certain anatomical conditions in infants is a significant cause of Sudden Infant Death Syndrome (SIDS), suggesting that sleeping in a semireclining position may reduce the risk of SIDS.
DOI: 10.1177/000992287801700504 -
Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: A randomized study
This study compares the efficacy and safety of terlipressin and noradrenaline in treating type 1 hepatorenal syndrome, finding no significant difference in response rates between the two treatments.
DOI: 10.1016/j.jhep.2012.01.012 -
A prospective evaluation of fatty pancreas by using EUS
This study prospectively evaluates the prevalence of fatty pancreas using endoscopic ultrasound (EUS) and identifies its association with metabolic syndrome and other risk factors.
DOI: 10.1016/j.gie.2011.01.015 -
Hydrocephalus in pfeiffer syndrome
This study reviews the clinical records and CT scan findings of 11 patients with Pfeiffer syndrome, revealing a high prevalence of hydrocephalus and its association with craniosynostosis, leading to significant clinical implications for management and prognosis.
DOI: 10.1016/0967-5868(94)90030-2 -
Low-Dose Aripiprazole Augmentation in Amitriptyline-Resistant Burning Mouth Syndrome: Results from Two Cases
This study presents two cases where low-dose aripiprazole augmentation significantly alleviated pain in patients with burning mouth syndrome resistant to amitriptyline treatment.
DOI: 10.1093/pm/pnw200 -
Mutation spectrum of the fibrillin‐1 ( FBN1 ) gene in Taiwanese patients with Marfan syndrome
This study establishes a national database of mutations in the fibrillin-1 (FBN1) gene associated with Marfan syndrome in Taiwanese patients, identifying 56 mutations in 62 of 157 families, with implications for genetic counseling and medical care.
DOI: 10.1111/j.1469-1809.2009.00545.x -
From first report to clinical trials: a bibliometric overview and visualization of the development of Angelman syndrome research
A bibliometric overview mapping the development of Angelman syndrome research over ~50 years, detailing publication trends, funding sources, collaboration networks, journal venues, and shifts from genetic/epigenetic study toward functional and therapeutic research, including ASO…
DOI: 10.1007/s00439-022-02460-x -
Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial
In the first-in-human phase 1 MagnetisMM-1 trial, single-agent subcutaneous elranatamab achieved an objective response rate of 63.6% with durable responses (median duration 17.1 months) and a manageable safety profile in heavily pretreated, triple-class-refractory relapsed/refra…
DOI: 10.1038/s41591-023-02589-w -
Openness and avoidance – a longitudinal study of fathers of children with intellectual disability
Fathers' experiences of parenting a child with ID/DD vary along an openness–avoidance continuum and evolve over five years, shaped by diagnosis and coping strategies, with three main themes.
DOI: 10.1111/jir.12093 -
High-precision Biomedical Text Corpora for Multi-Entity Recognition: A CoDiet study
This study describes the construction and release of four multi-entity biomedical text corpora (CoDiet-Gold, CoDiet-Bronze, CoDiet-Silver, CoDiet-Electrum) for metabolic-syndrome literature to advance multi-entity NER, detailing annotation pipelines, evaluation, and data/funding…
DOI: 10.1101/2025.09.04.673740 -
Cultural and biomedical meanings of the complaint of leukorrhea in South Asian women
This ethnographic study examines how leukorrhea in South Asian women is interpreted through both biomedical discourse on reproductive tract infection and culturally laden Ayurvedic ideas, arguing that the symptom functions as a culturally shaped idiom of distress with important …
DOI: 10.1046/j.1365-3156.2001.00699.x -
Association of rs9939609 Polymorphism with Metabolic Parameters and FTO Risk Haplotype Among Tunisian Metabolic Syndrome
This study investigates the association of the rs9939609 polymorphism in the FTO gene with metabolic syndrome components in a Tunisian population, revealing significant links between the variant and increased risks of metabolic syndrome and impaired fasting glucose levels.
DOI: 10.1089/met.2015.0090 -
Clinical remission of idiopathic hypereosinophilic syndrome in a Rottweiler
This study presents a case of clinical remission of idiopathic hypereosinophilic syndrome in a Rottweiler, detailing the diagnostic process, treatment, and long-term outcomes.
DOI: 10.1111/j.1751-0813.2009.00461.x -
Probable Blind Spot in the International Diabetes Federation Definition of Metabolic Syndrome
This study compares the cardiovascular profiles of patients defined by the International Diabetes Federation and the National Cholesterol Education Program definitions of metabolic syndrome, revealing that the IDF definition may overlook individuals with significant metabolic di…
DOI: 10.1038/oby.2007.633 -
Serum N-glycan profile shift during human ageing
This study investigates the serum N-glycan profile shifts during human aging and establishes the GlycoAgeTest as a potential biomarker for biological age, demonstrating its applicability in healthy individuals and patients with dementia and Cockayne syndrome.
DOI: 10.1016/j.exger.2010.08.009 -
Down's syndrome and atherosclerosis
This study investigates the prevalence and severity of atherosclerosis in Down's syndrome patients compared to other mentally retarded individuals and normal controls, finding that while Down's syndrome patients exhibit some atherosclerosis, it is significantly milder than in th…
DOI: 10.1016/0021-9150(89)90110-x -
Cardiovascular Fitness, Activity, and Metabolic Syndrome Among College Men and Women
This cross-sectional study investigates the relationship between cardiovascular fitness, physical activity levels, and the prevalence of metabolic syndrome among college students aged 18-24, revealing that those with below-average fitness are at significantly higher risk for obe…
DOI: 10.1089/met.2013.0011 -
Neuropsychiatric Symptoms and Syndromes in a Large Cohort of Newly Diagnosed, Untreated Patients With Alzheimer Disease
In a large cross-sectional cohort of 1,015 newly diagnosed, untreated Alzheimer's disease patients from five Italian memory clinics, neuropsychiatric symptoms assessed with the Neuropsychiatric Inventory clustered into five distinct syndromes (apathetic, affective, psychomotor, …
DOI: 10.1097/JGP.0b013e3181d6b68d