So I can use cannabis or not?

Yes, you can use cannabis instead of Tylenol for this ache. But nobody has run a trial of cannabis versus Tylenol for post-biopsy pain, so you are choosing on plausibility, not proof.

The closest human evidence is for chronic pain, not a few days of needle soreness. A narrative review of medicinal cannabis for chronic non-cancer pain found variable results: one year-long oil study reported improvement in about 65 in 100 patients, while a synthetic THC trial found only moderate pain improvement [5]. That review also flags that long-term safety remains uncertain [5]. The American Heart Association statement found no established cardiovascular benefit from cannabis and called the evidence on harm largely inconclusive [4]. For a healthy person taking it for a few days, that is a low but real unknown.

What you should know about the swap itself. THC-dominant cannabis raised post-exercise pulse pressure and heart rate in a small within-subject study of healthy users [2]. It also acutely impairs recognition memory in a dose-dependent way, and CBD co-use blunts that [3]. A CBD-dominant product reduced tension and anxiety without paranoia, while THC-dominant increased paranoia briefly [1]. If you want pain relief without the head high, a balanced or CBD-leaning product is the lower-risk choice on this evidence.

The bigger point: your post-biopsy risk is infection, not the ache. Cannabis will not touch that. If you get fever, chills, or trouble urinating, that is the signal to call, regardless of what you took for pain.

My call: cannabis is a reasonable substitute for Tylenol here, favoring a balanced or CBD-leaning product, but the evidence for this exact use does not exist and the cardiovascular and memory effects are real. Confidence: low.