Question explored with the scientific record
Conversation so far
- 1 what is naltrexone for/do? + a private exchange
- 2 what about use in long covid? + a private exchange
- 3 wgat does CoQ10 400mg do + a private exchange
- 4 Nattokinase what does it do?
- 5 and for long covid?
- 6 so nattokinase and ultrasound worked?
Answered on this page ↓
so nattokinase and ultrasound worked?
In a dish, yes. In a person with long COVID, nobody has shown it.
The two lab studies point in different directions. One found nattokinase broke down abnormal microclots and slowed new ones forming, in rough proportion to dose [1]. The other found nattokinase alone, without ultrasound, showed no significant reduction versus control, and that the ultrasound itself did most of the clot disruption [2]. So "it worked" depends on which dish you mean, and neither dish is a patient.
Ultrasound is the more interesting half of your question, and the evidence is thinner still. The same lab study is the only record here that tested it, and it tested it on pig plasma in a tube, not on anyone's body [2]. There is no human trial in this evidence of ultrasound for long COVID symptoms.
| Question | What the evidence shows |
|---|---|
| Nattokinase breaks microclots in a dish? | Yes, dose-dependent [1] |
| Nattokinase alone, no ultrasound? | No significant effect [2] |
| Ultrasound disrupts microclots in a dish? | Yes, mechanical force dominates [2] |
| Either one helps long COVID patients? | Not tested in this evidence |
What this evidence cannot see is the human layer: no trial here measures fatigue, breathlessness, or recovery in long COVID patients given either treatment. That is a gap in what I have, not proof the gap is permanent.
My call: the combination is a lab result, not a treatment. Do not read "it worked" as anything beyond a dish. Confidence: low.
Sources used 2
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Automated, Microscopic Measurement of Fibrinaloid Microclots and Their Degradation by Nattokinase, the Main Natto Protease
Recombinant nattokinase degraded ThT-positive fibrinaloid microclots in vitro, and automated fluorescence microscopy tracked microclot number, intensity, and size over time.
DOI: 10.62767/jecacm504.6557 -
Investigation of the Synergistic Effect of Enzymatic and Ultrasound-Induced Amyloid Microclot Degradation
This study investigates whether low-frequency ultrasound with microbubbles can mechanically disrupt amyloid microclots in vitro and whether fibrinolytic enzymes (rtPA, lumbrokinase, nattokinase) provide any synergistic enhancement, finding that ultrasound-driven mechanical force…
DOI: 10.1101/2025.09.12.675963