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  1. 1 Should i try adjd medication without a diagnosis, just a few weeks to see if it feels better
  2. 2 So will trying it for longer confirm things if you're saying a few weeks won't?

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So will trying it for longer confirm things if you're saying a few weeks won't?

Sep 22, 2026 · 4 sources used · OpenNeedle synthesis
A few weeks of self-experimentation cannot confirm an ADHD diagnosis, and extending the trial does not fix the core problem: you still lack a baseline, a blinded comparison, and a proper evaluation.

The placebo response is not a few days of wishful thinking. In a randomized, double-blind, cross-over n-of-1 trial of 133 drug-naïve children with ADHD, 18.8% showed a 30% or greater improvement on placebo alone, and 61.6% did as well or better on placebo as on methylphenidate [1]. That is not a brief honeymoon effect. It is a substantial, sustained response that persists across weeks of blinded treatment. If you try the drug for a month and feel better, you have no way to know whether you are in that 18.8% or the 61.6%, because you are not blinded and you have no baseline measure.

The longer you take it, the more you risk anchoring on a false positive. A positive response to a stimulant is not diagnostic. In the same trial, placebo response correlated with methylphenidate response, meaning the people who improved on sugar pills also improved on the drug [1]. That makes the self-experiment even more misleading: you cannot distinguish a genuine drug effect from your own expectation, and the overlap is so large that a "positive" result proves almost nothing.

The cardiovascular risks do not shrink with time. In a separate adult cohort, 10.9% reported adverse events, most commonly reduced appetite and headache [4]. Stimulants raise heart rate and blood pressure [2, 3]. Atomoxetine caused a mean heart rate increase of 9 beats per minute and a diastolic blood pressure increase of nearly 11 mmHg in one pediatric study [3]. A longer trial means more cumulative exposure to those effects, not less, and you still do not know if you have an underlying condition that amplifies them.

The only thing a longer trial confirms is whether the drug does something for you subjectively. It cannot tell you whether you have ADHD, whether the benefit is real or placebo, or whether the long-term risks are worth it. That requires a proper diagnostic evaluation, including baseline cardiovascular assessment, before you start.

My call: no, a longer trial will not confirm anything. It will only deepen the false certainty. Get the diagnosis first, or do not take the drug. Confidence: high.

Keep digging

Sources used 4

  1. The Short-Term Placebo Response in Children With Attention-Deficit Hyperactivity Disorder (ADHD) Journal of Child Neurology (2018) Thin

    This study used a randomized, double-blind, cross-over n-of-1 trial in 133 drug-naïve children with ADHD to quantify short-term placebo response, finding 18.8% showed ≥30% placebo improvement on teacher-rated ADHD symptoms, with placebo response correlating with methylphenidate …

    DOI: 10.1177/0883073818756403
  2. Efficacy of Adderall and Methylphenidate in Attention Deficit Hyperactivity Disorder: A Reanalysis Using Drug–Placebo and Drug–Drug Response Curve Methodology Thin

    Adderall shows clinically meaningful, broad improvements over placebo and methylphenidate across the full spectrum of ADHD symptom change and also helps prevent worsening in children, as revealed by drug–placebo and drug–drug response curves.

    DOI: 10.1089/104454601750284081
  3. Evaluation of a head-to-head study of lisdexamfetamine dimesylate and atomoxetine Expert Opinion on Pharmacotherapy (2014) Thin

    A head-to-head randomized trial in children and adolescents with ADHD and inadequate response to methylphenidate shows lisdexamfetamine dimesylate (LDX) provides faster and greater improvement in ADHD symptoms than atomoxetine (ATX) over 9 weeks, with safety profiles consistent …

    DOI: 10.1517/14656566.2014.934811
  4. Methylphenidate and Comorbid Anxiety Disorder in Children With Both Chronic Multiple Tic Disorder and ADHD Journal of Attention Disorders (2010) primary study Strong

    Co-occurring anxiety disorder in children with chronic multiple tic disorder and ADHD was not associated with a less favorable response to immediate-release methylphenidate after controlling for ODD severity.

    DOI: 10.1177/1087054709356405

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