Question explored with the scientific record
Conversation so far
- 1 If you have hypoventilation due to autonomic neuropathy or blunted chemorecptors what is the best intervention + a private exchange
- 2 Is the link between late diagnosed celiac and autonomic disorders established?
- 3 Is there an established link between celia disease and neuropathy?
- 4 Is the study done in England (sheffield?)using a huge dataset of celiac patients included
Answered on this page ↓
Is the study done in England (sheffield?)using a huge dataset of celiac patients included
The short version: the retrieved evidence does not include a Sheffield-based large-dataset study of celiac patients and neuropathy, so the specific study you are asking about is not in these records.
The evidence here contains several studies on celiac disease and neuropathy, but none from Sheffield and none using a large dataset. A 2010 study of 274 celiac patients (125 elderly, 149 young adults) found neuropathy in 11% of the elderly and 4% of the young adults [2], but that was a clinical comparison, not a population-level dataset. A 2005 study of 26 well-controlled celiac patients found 23% had peripheral neuropathy on testing [1], but again a small clinical sample.
The retrieval also includes a 2025 study using TCRβ repertoire sequencing from 884 celiac cases and 3,624 controls [3], and a 2025 whole-genome RNA sequencing study of 283 pediatric samples [4], but neither addresses neuropathy at all. A 2008 study on celiac disease and type 1 diabetes mentions peripheral nerve function in its title but the extracted data covers haptoglobin polymorphism, not nerve outcomes [5].
What is missing: any population-level study from Sheffield, any UK-based large dataset on celiac patients, and any study that systematically measures neuropathy rates across a large celiac cohort. The question of whether a specific Sheffield study found an association with neuropathy cannot be answered from these records.
My call: the evidence here does not contain the study you are asking about. The link between celiac disease and neuropathy is supported by smaller clinical studies [1][2], but no large-dataset Sheffield study is present in this retrieval.
Confidence: high that the specific study is absent from these records.
Sources used 5
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Peripheral neuropathy and celiac disease
This study explores the relationship between peripheral neuropathy and celiac disease, highlighting the prevalence of neurologic manifestations and the potential role of gluten-free diets and immunomodulatory treatments in managing these conditions.
DOI: 10.1007/s11940-005-0005-3 -
Celiac Disease: Similar Presentations in the Elderly and Young Adults
This study compares the clinical and histological presentations of celiac disease in elderly patients (aged 65 and older) and young adults (aged 18-30), finding that both groups exhibit similar symptoms and disease characteristics despite the elderly cohort's higher prevalence o…
DOI: 10.1007/s10620-010-1142-4 -
Shared TCRs in peripheral blood offer robust celiac disease classification independent of gluten Intake
This study uses bulk TCRβ repertoire sequencing of peripheral blood from biopsy-confirmed celiac disease patients and controls to identify hundreds of disease-associated public TCRs (enhanced sequences), demonstrates that these sequences classify CeD robustly independent of glut…
DOI: 10.64898/2025.12.26.696039 -
Whole genome transcriptional analysis of intestinal biopsies and blood cells indicate genes involved in antioxidant defense systems, amino acid metabolism and antigen presentation in the pathogenesis of celiac disease
This study uses whole-genome RNA sequencing of intestinal biopsies and peripheral blood from pediatric celiac disease patients and disease controls to identify coordinated differential expression across oxidative defense, amino acid metabolism, and antigen presentation pathways,…
DOI: 10.1186/s12916-025-04261-1 -
S1258 What Are the Implications of Newly Identified Celiac Disease in Patients with Type 1 Diabetes Mellitus? Effect Upon Glycaemic Control, Quality of Life, Cardiac Risk Factors and Peripheral Nerve Function
This study investigates the association of haptoglobin polymorphism with susceptibility to celiac disease and its clinical presentations in a cohort of Hungarian patients.
DOI: 10.1016/s0016-5085(08)60980-4