Tell me about primodos and who funds

Primodos was a pregnancy test pill, not a treatment. The retrieved evidence shows its two hormones can deform embryos, but says nothing about who funded or made it.

Primodos was a hormonal pregnancy test taken by women in the 1950s to 1970s. It contained two synthetic hormones, norethisterone acetate and ethinyl estradiol [1]. A 2018 zebrafish study found these compounds caused developmental defects in a dose- and time-dependent way: at the highest dose, 100% of embryos died, and at a mid dose, 92% showed defects and half died [1]. That is animal evidence, not proof of what happened in human pregnancies, but it shows the mechanism is real.

Who funds it is a different question. The records here contain no funding disclosure, no manufacturer name, and no trial data for Primodos itself. The other 14 records are about unrelated prenatal exposures like bisphenols, parabens, and pesticides, and they do not touch Primodos or its maker. So I cannot name a funder from this evidence.

My call: the hormone components are demonstrably harmful to developing embryos in animal models [1], but the funding question is unanswered by this evidence. Confidence: moderate on the mechanism, low on who funded it.