Question explored with the scientific record
Conversation so far
- 1 Create a model of pathogenesis regarding how a flu vaccine triggers warm aiha? Show me the best plausible theory from injection to injury in 2-6 week onset.
- 2 Are there any case reports or registries linking flu shots to warm AIHA?
Answered on this page ↓
Are there any case reports or registries linking flu shots to warm AIHA?
The evidence you retrieved does not contain a single case report or registry entry linking flu shots to warm AIHA. That absence is the finding.
None of the 32 records in your evidence set describes a patient who developed warm autoimmune hemolytic anemia after influenza vaccination. The closest you get is a general pharmacovigilance overview [25] that explains how databases like VAERS and VigiBase work, and a study of vaccine-associated chronic urticaria [29] that lists influenza vaccine among the types reported. Neither is a case of AIHA. The rest of the evidence is about vaccine effectiveness in mice [1], university students' vaccine attitudes [2], and case reports of hernias [19], brain tuberculomas [20], and omental gangrene [13] — none of which address your question.
The mechanism I described in the previous answer is still biologically coherent: a vaccine that activates B cells broadly can, in a predisposed person, expand a clone that makes IgG against red cell surface proteins, with the 2-6 week window matching the time for affinity maturation. But a plausible mechanism is not evidence that it happens. The published literature has not documented this specific link in any case report or registry analysis that you provided.
My call: there are no case reports or registry entries in the evidence you retrieved that link flu shots to warm AIHA. The mechanism is plausible but unconfirmed. Confidence: low, because the relevant surveillance was never shown to have captured this outcome.
Sources used 32
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Cell-Cultured Influenza Vaccine Enhances IFN-γ+ T Cell and Memory T Cell Responses Following A/Victoria/2570/2019 IVR-215 (A/H1N1) Infection
This study compares the immune responses elicited by cell-cultured and egg-based influenza vaccines in BALB/c mice, demonstrating that the cell-cultured vaccine significantly enhances T cell responses and offers potential advantages for long-term immunity.
DOI: 10.3390/vaccines12121392 -
Low uptake of influenza vaccine among university students: Evaluating predictors beyond cost and safety concerns
This study evaluates the low uptake of influenza vaccination among university students, identifying barriers to vaccination and the potential impact of educational interventions on increasing vaccine acceptance.
DOI: 10.1016/j.vaccine.2015.02.033 -
Superior Relative Efficacy of Live Attenuated Influenza Vaccine Compared With Inactivated Influenza Vaccine in Young Children With Recurrent Respiratory Tract Infections
A multicenter, randomized phase III trial in 6- to 71-month-old children with recurrent respiratory tract infections shows that cold-adapted influenza vaccine, trivalent (CAIV-T) provides superior protection against culture-confirmed influenza strains antigenically similar to th…
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A comprehensive, up-to-date review of the global health impact of influenza, current vaccination strategies, and the evolving role of nanotechnology in influenza vaccine development, including challenges and future directions toward universal vaccines.
DOI: 10.3390/vaccines13090890 -
Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, Canada
This study compares the effectiveness of live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) in preventing laboratory-confirmed influenza among children aged 2 to 17 years during the 2012-2013 to 2015-2016 influenza seasons in Alberta, Canada, findin…
DOI: 10.1001/jamapediatrics.2018.1514 -
The effectiveness of influenza vaccination in preventing hospitalisation in children in Western Australia
This study evaluates the effectiveness of the trivalent inactivated influenza vaccine (TIV) in preventing hospitalizations due to laboratory-confirmed influenza in children in Western Australia, finding a vaccine effectiveness of 62.3% with low vaccine uptake.
DOI: 10.1016/j.vaccine.2015.10.122 -
Induction of Cross-Neutralizing Antibody Against H5N1 Virus After Vaccination with Seasonal Influenza Vaccine in COPD Patients
This study investigates the induction of cross-neutralizing antibodies against the H5N1 virus in elderly COPD patients following vaccination with a seasonal influenza vaccine, revealing that vaccination, rather than influenza illness, is responsible for the observed antibody res…
DOI: 10.1089/vim.2009.0082 -
Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China
This study estimates the effectiveness of the influenza vaccine against hospitalization due to influenza in Beijing during the 2015/16 season, finding that vaccination did not provide effective protection.
DOI: 10.1016/j.vaccine.2017.03.084 -
Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccine
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Safety of Simultaneous Vaccination With Adjuvanted Zoster Vaccine and Adjuvanted Influenza Vaccine
A randomized, blinded clinical trial in adults aged 65 and older found that simultaneous vaccination with the adjuvanted recombinant zoster vaccine (RZV) and an adjuvanted influenza vaccine (aIIV4) has noninferior safety compared with simultaneous vaccination of RZV and high‑dos…
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Evaluation of influenza vaccination in health-care workers, using rapid antigen detection test
This study assesses the effectiveness of the trivalent influenza vaccine in preventing influenza and reducing absenteeism among health-care workers at Gifu Red Cross Hospital, demonstrating significant reductions in both influenza infections and work absenteeism among vaccinated…
DOI: 10.1007/s10156-005-0424-9 -
Glandular odontogenic cyst (sialo‐odontogenic cyst): report of two cases and literature review of 45 previously reported cases
This case report presents the clinical, radiological, histopathological, and immunohistochemical features of two cases of glandular odontogenic cyst (GOC), contributing to the understanding of this rare lesion and its recurrence rates based on a review of 45 previously reported …
DOI: 10.1111/j.1600-0714.1998.tb01984.x -
Primary omental gangrene mimicking appendicular perforation peritonitis—A case report
This is a case report of a 47-year-old man with primary omental torsion presenting as appendicular perforation peritonitis, treated with omentectomy and peritoneal lavage, highlighting diagnostic challenges and surgical management.
DOI: 10.1016/j.ijscr.2016.02.026 -
Severe pneumonia due to concurrent Legionella pneumophila and Acinetobacter baumannii infections: a case report
This case report describes a rare instance of severe pneumonia caused by concurrent infections of Legionella pneumophila and Acinetobacter baumannii in a 45-year-old male, highlighting the importance of early pathogen detection and appropriate antibiotic treatment.
DOI: 10.1186/s12890-025-03481-8 -
Recurrent Posterior Reversible Encephalopathy Syndrome Potentially Related to AIDS and End-Stage Renal Disease: A Case Report and Review of the Literature
This case report describes a 28-year-old woman with HIV and end-stage renal disease who experienced recurrent Posterior Reversible Encephalopathy Syndrome (PRES), highlighting the multifactorial nature of the condition and the need for careful management of hypertension in such …
DOI: 10.1155/2012/914035 -
A case of stroke as a unique sign of subclinical infective endocarditis by Abiotrophia defectiva: a case report
This case report describes a unique instance of stroke as a sign of subclinical infective endocarditis caused by Abiotrophia defectiva, highlighting the challenges in diagnosis and the importance of timely intervention.
DOI: 10.1186/s12245-025-00814-6 -
Rapid Resolution of Acute Fulminant Myocarditis after IVIG and Steroid Treatment
This case report describes the rapid recovery of a 59-year-old woman with acute fulminant myocarditis after treatment with intravenous immunoglobulin (IVIG) and steroids, despite the lack of evidence supporting immunosuppressive therapies in viral myocarditis.
DOI: 10.1155/2012/262815 -
Pigmented Villonodular Synovitis Causing Osteonecrosis of the Femoral Head: A Case Report
This case report describes a 27-year-old man with pigmented villonodular synovitis (PVNS) leading to osteonecrosis of the femoral head, highlighting the potential contribution of PVNS to the pathogenesis of osteonecrosis and the successful surgical intervention performed.
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Primary Jean Louis Petit and Grynfeltt-Lesshaft concomitant hernias: A case report
This case report describes a rare instance of concomitant Jean Louis Petit and Grynfeltt-Lesshaft hernias in a 67-year-old male patient, highlighting the challenges in diagnosis and surgical management in a resource-limited setting.
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Brain Tuberculomas: A Case Report
This case report details a rare instance of brain tuberculomas in a 15-year-old girl, highlighting the diagnostic challenges and successful treatment with anti-tuberculosis drugs following surgical intervention.
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Granulomatosis with polyangiitis presenting with pelvic mass leading to total hysterectomy: A case-letter
This case report describes a rare manifestation of Granulomatosis with Polyangiitis (GPA) presenting as cervical necrotizing vasculitis in a 33-year-old woman, highlighting the need for awareness of this condition to prevent unnecessary surgical interventions.
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Familial trophoblastic disease: Case report
This case report discusses familial trophoblastic disease, specifically repeated hydatidiform moles occurring in two sisters married to two brothers, highlighting potential genetic and environmental factors in its etiology.
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Orbital metastasis as primary clinical manifestation of thyroid carcinoma: case report and literature review
This clinical case report describes a rare instance of orbital metastasis from papillary thyroid carcinoma (PTC) in a 66-year-old woman, highlighting the importance of considering thyroid carcinoma in cases of orbital metastasis.
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Brachial plexopathy associated with Q fever: Case report and review of the literature
This case report describes a 35-year-old man with recurrent Q fever who developed brachial plexopathy, highlighting the potential neurologic complications associated with Q fever and the successful resolution of symptoms following antibiotic treatment.
DOI: 10.1002/mus.21104 -
Uses of pharmacovigilance databases: An overview
A narrative overview of how pharmacovigilance databases (e.g., VigiBase, EVDAS, FPDB, FAERS/VAERS) are used for signal detection and pharmacoepidemiology, detailing methods (IC/BCPNN, PRR, ROR, MGPS/EBGM) and emphasizing data quality and orthogonal validation of safety signals.
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Prescribed drugs and violence: a case/noncase study in the French PharmacoVigilance Database
This study identifies prescribed drugs associated with violent behaviors using the French PharmacoVigilance Database, revealing significant associations with dopaminergic agonists, benzodiazepines, and serotoninergic antidepressants, among others.
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Serotonin Syndrome
This study analyzes 125 cases of serotonin syndrome reported in the French pharmacovigilance database, highlighting the involvement of serotonergic drugs and the nature of drug-drug interactions.
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Drug‐induced vitiligo: a case/non‐case study in Vigibase ® , the WHO pharmacovigilance database
A retrospective disproportionality analysis of the WHO Vigibase pharmacovigilance database identifies drugs and drug classes associated with vitiligo, confirming known links with immune checkpoint inhibitors and revealing signals for imiquimod, interferons, TNF-α inhibitors, int…
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Global Burden of Vaccine-Associated Chronic Urticaria, 2010–2023: From the Global Pharmacovigilance Database
This study investigates the global burden and long-term trends of vaccine-associated chronic urticaria (CU), focusing on the associated vaccines and the distribution of cases across different age groups and sexes, using data from the World Health Organization's international pha…
DOI: 10.4168/aair.2024.16.6.613 -
Statin-induced lupus: a case/non-case study in a nationwide pharmacovigilance database
This study investigates the potential link between statin use and the induction of lupus erythematosus using a case/non-case analysis of adverse drug reaction reports in the French PharmacoVigilance Database, finding a reporting odds ratio of 1.67 for statin exposure in lupus ca…
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Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis: Global Pharmacovigilance Data
Global pharmacovigilance analysis of nintedanib safety in idiopathic pulmonary fibrosis (IPF) using spontaneous and solicited reports from 2014–2018; diarrhea was the most frequent adverse event and several safety signals (liver enzyme elevations, bleeding, MACE, myocardial infa…
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Reports of hypoglycaemia associated with the use of ACE inhibitors and other drugs: a case/non‐case study in the French pharmacovigilance system database
This study investigates the association between reports of hypoglycaemia and the use of angiotensin converting enzyme inhibitors (ACEI) in the French pharmacovigilance database, revealing that the association is primarily linked to concomitant use of antidiabetic agents.
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