Question explored with the scientific record
Conversation so far
- 1 What was the exact reason why avacopan was withdrawn from the Uk market
- 2 Can we check MHRA or UK regulator databases for any withdrawal notice?
Answered on this page ↓
Can we check MHRA or UK regulator databases for any withdrawal notice?
No withdrawal notice for avacopan appears in the records retrieved.
The 22 records include a 2026 case report on avacopan for severe vasculitis [1], but none are regulatory filings, MHRA announcements, or commercial discontinuation notices. The retrieval contains no document from any UK regulator database that mentions avacopan at all.
This means the searches did not surface the kind of record you are asking about. A withdrawal notice, if one exists, would be a regulatory document posted on the MHRA website or the UK Drugs Database. The retrieval system used here does not appear to have searched those specific databases, or if it did, it returned nothing matching.
My call: the evidence retrieved contains no MHRA or UK regulator withdrawal notice for avacopan. Confidence: not clear — the retrieval simply did not cover the relevant databases.
Sources used 1
-
Avacopan for severe pulmonary hemorrhage requiring extracorporeal membrane oxygenation in a patient with MPO-ANCA positive vasculitis
A life-threatening MPO-ANCA vasculitis case with diffuse alveolar hemorrhage requiring ECMO was successfully treated with avacopan plus standard immunosuppression, enabling rapid taper and withdrawal of prednisone within six months.
DOI: 10.1007/s13730-025-01068-0