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- 1 NAC 600mg + NAD Would this help ex smoker and someone with COPD
- 2 Would NMN be a good supplement for a 60 year old
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Would NMN be a good supplement for a 60 year old
The short version: NMN raises blood NAD reliably in healthy middle-aged adults, but no retrieved study tests whether that helps a 60-year-old ex-smoker's lungs or COPD risk.
The strongest evidence comes from a 2024 systematic review of six RCTs: oral NMN at 250–900 mg/day for 10–12 weeks significantly increased blood NAD in 275 adults aged 40–65, with only mild side effects [3]. A separate 60-day dose-ranging trial in 80 healthy adults found NMN improved walking distance and prevented a rise in biological age, but also saw HOMA-IR (a marker of insulin resistance) increase in the 600 mg and 900 mg groups [4]. That last finding matters for someone with metabolic risk.
What the retrieval does not contain: a single study testing NMN in ex-smokers, COPD patients, or anyone with lung disease. The closest is the walking-distance improvement in healthy adults [4], which hints at better aerobic capacity but does not prove lung-specific benefit. The 2023 arterial-stiffness trial found only a trend toward reduced stiffness overall, with significant effects only in subgroups with above-average BMI or blood glucose [1] — not your question's population.
| Outcome | NMN (250–900 mg/day) | Placebo |
|---|---|---|
| Blood NAD increase | Significant in all doses [3] | None |
| Six-minute walking distance | Improved at 600–900 mg [4] | No change |
| HOMA-IR (insulin resistance) | Rose at 600–900 mg [4] | No change |
| Lung function or COPD flares | Not studied | — |
The meta-analysis of NAD precursors also found they significantly raise plasma glucose [2], which is worth watching if blood sugar is a concern. The safety data covers only 60–84 days [3][4]; no long-term study appears in this retrieval.
My call: NMN raises NAD and may improve walking endurance, but for a 60-year-old ex-smoker wondering about lung health, the evidence is absent. Confidence: high that NMN boosts blood NAD; not clear for any lung or COPD benefit.
Sources used 4
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Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial
A 12-week randomized, double-blind, placebo-controlled trial in 36 healthy middle-aged adults found that 250 mg/day nicotinamide mononucleotide (NMN) was safe and significantly increased serum nicotinamide levels, while only a trend toward reduced arterial stiffness (baPWV) was …
DOI: 10.1038/s41598-023-29787-3 -
Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis
Pooled NAD+ precursor supplementation significantly lowered triglycerides; nicotinic acid showed the largest effects on lipids and glucose, plasma glucose increased, and NR/NAM did not significantly affect lipid metabolism.
DOI: 10.1186/s12986-022-00653-9 -
EFFICACY OF NICOTINAMIDE MONONUCLEOTIDE SUPPLEMENTATION (NMN) IN BLOOD NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) FOR ANTI-AGING IN ADULTS: A SYSTEMATIC REVIEW
A systematic review of six RCTs found that oral NMN supplementation (250–900 mg/day for 10–12 weeks) significantly increased blood NAD concentrations in adults, with only mild adverse effects, supporting its potential anti-aging benefit.
DOI: 10.61841/gyj2gr52 -
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
In a 60-day double-blind dose-ranging trial in 80 healthy middle-aged adults, oral NMN (300-900 mg/day) raised blood NAD, improved walking distance, and prevented biological-age increase while being safe, although HOMA-IR rose in the 600 and 900 mg groups.
DOI: 10.1007/s11357-022-00705-1