Question explored with the scientific record
Conversation so far
- 1 What evidence is there that dietary changes can help inflammation
- 2 Which inflammatory markers change most with diet, and are they consistent?
- 3 What exactly is a Mediterranean diet
- 4 Why was the predicted trial cut short
Answered on this page ↓
Why was the predicted trial cut short
The evidence retrieved does not name a specific trial cut short for dietary changes for inflammation.
The records here cover Mediterranean diet effects on inflammation in several populations [1, 2, 3, 4, 5, 6, 7, 8, 9, 10], but none describes a trial that was stopped early. The PREDIMED trial, which the previous answer mentioned, is not in this evidence block. The closest match is the AVERROES trial of apixaban, which was stopped early for efficacy [11], but that is a blood thinner, not a dietary intervention for inflammation.
The question asks about a "predicted trial" — a trial that was forecast or expected. No record in this retrieval describes a trial that was predicted and then cut short. Without a named trial, the question cannot be answered from these studies.
My call: the evidence does not identify any trial matching the description. Confidence: not clear.
Sources used 11
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Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease
Prospective cohort study examining whether adherence to the Mediterranean diet reduces Alzheimer's disease risk in older adults and whether inflammatory (hsCRP) and metabolic (insulin, adiponectin) biomarkers mediate this association, finding lower AD risk with higher MeDi adher…
DOI: 10.3233/JAD-2010-100897 -
Mediterranean-type diets and inflammatory markers in patients with coronary heart disease: a systematic review and meta-analysis
A systematic review and meta-analysis of Mediterranean-type diets in patients with coronary heart disease (CHD) found that observational studies show inverse associations with inflammatory markers, but randomized/controlled trials largely show non-significant reductions in CRP c…
DOI: 10.1016/j.nutres.2017.10.014 -
The antioxidant potential of the Mediterranean diet in patients at high cardiovascular risk: an in-depth review of the PREDIMED
Polyphenol-rich Mediterranean diet enhances endogenous antioxidant defenses and reduces inflammatory biomarkers in high-CVD-risk individuals, correlating with a lower incidence of major cardiovascular events in the PREDIMED framework.
DOI: 10.1038/s41387-018-0025-1 -
Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia
A multicenter cross-sectional study of adults with molecularly confirmed familial hypercholesterolemia from Brazil and Spain found that higher adherence to a Mediterranean diet is associated with more favorable dyslipidemia and inflammatory biomarker profiles (lower LDL-C, ApoB,…
DOI: 10.1016/j.numecd.2021.04.006 -
The Effectiveness of Mediterranean Diet in Nonalcoholic Fatty Liver Disease Clinical Course: An Intervention Study
Adherence to a Mediterranean diet for 6 months improves anthropometric, metabolic, and inflammatory biomarkers in adults with nonfibrotic NAFLD, with a nutrigenetic difference in visfatin response linked to STAT3 rs2293152 genotype while diet composition remains largely genotype…
DOI: 10.1089/jmf.2018.0020 -
Mediterranean diet and osteoarthritis: an update
This narrative review reports that greater Mediterranean diet adherence is associated with beneficial knee osteoarthritis outcomes, but the evidence is limited and causality remains unestablished.
DOI: 10.1007/s40520-024-02883-8 -
The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer’s disease
A 5-year prospective cohort study in 1,500 adults (750 healthy controls and 750 Alzheimer's disease patients) comparing long-term neuroprotective effects of the Mediterranean and MIND diets, showing higher diet adherence is associated with better cognitive function and slower bi…
DOI: 10.1038/s41598-025-17055-5 -
Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials
This systematic review and meta-analysis of randomized controlled trials demonstrates that adherence to a Mediterranean dietary pattern significantly reduces inflammation and improves endothelial function, as evidenced by various biomarkers.
DOI: 10.1016/j.numecd.2014.03.003 -
Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men
This study demonstrates that a Mediterranean-like diet and n-3 fatty acid supplementation significantly reduce serum levels of interleukin-18 in elderly high-risk men, potentially contributing to cardiovascular protection.
DOI: 10.1016/j.metabol.2009.04.031 -
Abstract: 1030 SERUM LEVELS OF INTERLEUKIN-18 ARE REDUCED BY DIET AND N-3 FATTY ACID INTERVENTION IN ELDERLY HIGH-RISK MEN
This study investigates the effects of dietary counseling and n-3 fatty acid supplementation on serum levels of interleukin-18 and other inflammatory markers in elderly high-risk men, finding significant reductions in IL-18 levels associated with both interventions.
DOI: 10.1016/s1567-5688(09)70386-1 -
Apixaban
A narrative review of apixaban's pharmacology and early trial results, showing it as a promising oral, fixed-dose factor Xa inhibitor with efficacy in VTE prophylaxis and AF stroke prevention, though long-term safety versus vitamin K antagonists remained unproven.
DOI: 10.4081/itjm.2011.128