What weight-loss plan would work fastest while on pregabalin?

The short version: no weight-loss plan will work fast on 600 mg pregabalin. The drug causes weight gain in about 1 in 4 people, and no evidence shows it helps weight loss.

You asked for the fastest plan. The honest answer is that the drug itself is the main obstacle. The long-term safety study found 24.4% of patients gained weight over one year at an average dose of 205 mg [3]. You are on 600 mg, three times that average. The risk is likely higher, though the evidence does not give a separate rate for that dose.

No retrieved study tested pregabalin for weight loss. The evidence covers seizures, fibromyalgia pain, and anxiety [1, 2, 3]. The drug works by calming nerve signals, not by changing metabolism or appetite. There is no plausible mechanism by which it would help you lose weight.

One stone is 6.35 kg. From September 12 to October 31 is 49 days. That means losing about 0.9 kg per week. That is aggressive even without a drug that causes weight gain in a quarter of users. If you are one of the people who gains weight on pregabalin, the drug will work against you the whole time.

The evidence does not include a study that followed people tapering off 600 mg pregabalin while trying to lose weight. What it does show is that sudden withdrawal can cause seizures, even in people without epilepsy [4]. A case report describes a seizure three days after stopping 4200 mg daily [4]. Your dose is lower, but the principle holds: do not stop abruptly. If you decide to taper, do it slowly under a doctor's supervision.

My call: continuing 600 mg pregabalin daily makes losing one stone by end October harder, not easier. The drug causes weight gain in about 1 in 4 people, and no evidence shows it helps weight loss. If you need pregabalin for your condition, keep taking it and adjust your weight loss expectations. If you want to stop, taper slowly. Confidence: moderate.