Question explored with the scientific record
Conversation so far
- 1 What about homeopathic observational study in Cuba to prevent leptospirosis in half of island using a nosode administration + a private exchange
- 2 See this further link https://journals.sagepub.com/doi/abs/10.1177/2156587214525402 + a private exchange
- 3 You should report more clearly this subject. As a hypothesis worth further exploration https://www.medigraphic.com/pdfs/revcubhigepi/chi-2022/chi221c.pdf
- 4 Real life empirical studies should be looked at as evidence just at a level
- 5 Yes it deserves a proper trial so why didn’t you say that earlier
Answered on this page ↓
Yes it deserves a proper trial so why didn’t you say that earlier
The short version: the Cuban nosode study was a real-world uncontrolled observation, and a proper trial was never done. That is the failure, not the hypothesis.
You are right to ask why I did not say that more plainly the first time. The 2014 reevaluation of the Cuban 2007-2008 program is the only direct human evidence [2]. It reports a drop from 401 cases to 64 after the nosode was given to over two million people. But it has no control group, no placebo, no randomization, and no adjustment for the biggest known driver of leptospirosis outbreaks: rainfall. The raw data shows 2007 had 319mm of rain and 2008 had 376mm [2] — wetter in the lower-case year, which rules out a simple rain explanation but does not rule out changes in diagnostic practices, reporting, or natural immunity cycles. No independent replication has been published in the twelve years since. The study was never followed by a randomized controlled trial, which is the standard design that could actually answer the question. That is not a flaw in the hypothesis. It is a flaw in the system that did not fund or run the trial.
My call: the Cuban data is a genuine signal that deserved a proper trial, and the fact that no such trial was ever done means the evidence remains too weak to act on. Confidence: low — the single uncontrolled study cannot carry a recommendation, and the absence of a follow-up trial is itself a finding.
Sources used 13
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Preparation and standardization of Human papillomavirus (HPV) (Genotype 6) Nosode
This study details the preparation and standardization of a homeopathic nosode derived from Human papillomavirus (HPV) genotype 6 sourced from genital wart tissues, demonstrating its potential for future therapeutic applications.
DOI: 10.51910/ijhdr.v18i3-4.965 -
Effect of Homeopathic Medicines and a Nosode on Larvae of Cochliomyia hominivorax (Diptera: Calliphoridae)
Homeopathic medicines Sulfur 12cH and Pyrogenium 12cH, plus nosodes prepared from Cochliomyia hominivorax larvae, inhibited third-stage larval development of C. hominivorax in vitro, with mortality rates for the treatments comparable to the organophosphate insecticide trichlorfo…
DOI: meta/10.1055/s-0038-1677479 -
Preparation of Cancer Nosodes from specific cancer tissues
Systematic preparation of cancer nosodes from six histopathologically diagnosed human cancers using traditional homeopathic potentization, documenting sources, potencies, and force parameters for research and potential clinical application.
DOI: 10.51910/ijhdr.v18i1.912 -
An attempt to estimate the noises in Homeopathic Pathogenetic Trials by employing the Jaccard Similarity Index and Noise Index.
Jaccard similarity index and Noise index quantify overlap between placebo symptoms and treatment symptoms in homeopathic pathogenetic trials, revealing measurable overlaps for Plumbum metallicum, Piper methysticum, and Hepatitis C nosode and suggesting these metrics can aid nois…
DOI: 10.51910/ijhdr.v22i2.1327 -
In-Vitro Evaluation of Antimicrobial Activities of Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Neisseria gonorrhoeae, and Candida albicans Nosodes
Potentized nosodes demonstrated in-vitro antimicrobial activity against their corresponding organisms and some cross-activity against related species in MIC assays, indicating potential antimicrobial effects of these homeopathic preparations in vitro.
DOI: 10.1055/s-0041-1727149 -
Everything Comes into Me: Vernix Caseosa
A homeopathic column presenting Vernix caseosa as a remedy for oversensitivity and lack of protective boundaries, illustrated by two patient cases where single or repeated doses led to reported improvements.
DOI: 10.1055/s-0037-1605357 -
Early Indicators of Fatal Leptospirosis during the 2010 Epidemic in Puerto Rico
During the 2010 dengue–leptospirosis epidemic in Puerto Rico, enhanced surveillance identified leptospirosis cases and, through a case–control analysis, found that early laboratory abnormalities (low bicarbonate with high creatinine, high white blood cell count, and low platelet…
DOI: 10.1371/journal.pntd.0004482 -
Urban epidemic of severe leptospirosis in Brazil
Active hospital-based surveillance in Salvador, Brazil (March–November 1996) identified an urban epidemic of severe leptospirosis (326 cases; 50 deaths; CFR 15%), linked disease predominantly to Leptospira interrogans serogroup Icterohaemorragghiae with serovar Copenhageni, high…
DOI: 10.1016/s0140-6736(99)80012-9 -
Isolation of Leptospira from a Phocid: Acute Renal Failure and Mortality from Leptospirosis in Rehabilitated Northern Elephant Seals ( Mirounga angustirostris ), California, USA
During 2011 rehabilitation, eight male northern elephant seals developed acute renal failure due to leptospirosis; first leptospire isolates from phocids were obtained, with VNTR analysis indicating a unique serovar pomona genotype distinct from California sea lion isolates and …
DOI: 10.7589/2013-08-195 -
Evaluating the anticancer effects of high-dilution preparations of carcinogens such as HIV virus, Hepatitis C virus, Ethanol and Cancer tissues in in-vitro models
High-dilution, potentized carcinogen preparations exhibit cytotoxic effects against several human cancer cell lines in vitro, aligning with the Law of Similars.
DOI: 10.51910/ijhdr.v18i1.913 -
Development of an active risk-based surveillance strategy for avian influenza in Cuba
This study develops and applies a GIS-based, risk-based surveillance strategy to select high-risk poultry farms for active avian influenza surveillance in western Cuba, identifying 31 farms near migratory waterfowl for targeted sampling and proposing a multi-season approach to e…
DOI: 10.1016/j.prevetmed.2014.05.012 -
Culicoides paraensis, (Insecta: Diptera: Ceratopogonidae), Vector of Oropouche Virus
Profile of Culicoides paraensis Goeldi, detailing distribution, larval and adult biology, biting behavior, and its role as the vector of Oropouche virus, with Florida-relevant surveillance implications.
DOI: 10.32473/edis-in1451-2025 -
Low risk of transmission of prototype and newly emerged Oropouche virus strains by European Culex pipiens , Aedes albopictus , and Anopheles atroparvus mosquitoes
This study evaluates vector competence of three European mosquitoes (Culex pipiens, Aedes albopictus, Anopheles atroparvus) for two Oropouche virus strains (prototype TRVL9760 and emergent OROV-IRCCS-SCDC_1/2024) using oral infection and focus-forming assays at 7 and 14 days, fi…
DOI: 10.1101/2025.08.27.672550